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Pathogenesis and therapy of lung cancer

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Published by M. Dekker in New York .
Written in English


  • Lungs -- Cancer.,
  • Lungs -- Cancer -- Etiology.,
  • Lung neoplasms -- Etiology.,
  • Lung neoplasms -- Therapy.

Book details:

Edition Notes

Includes bibliographical references and indexes.

Statementedited by Curtis C. Harris.
SeriesLung biology in health and disease ;, v. 10
ContributionsHarris, Curtis C., 1943-
LC ClassificationsRC756 .L83 vol. 10, RC280.L8 .L83 vol. 10
The Physical Object
Paginationxix, 762 p. :
Number of Pages762
ID Numbers
Open LibraryOL4729306M
ISBN 100824765915
LC Control Number78017321

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  The pathophysiology of lung cancer is very complex and incompletely understood. It is hypothesized that repeated exposure to carcinogens, cigarette smoke in-particular, leads to dysplasia of lung epithelium. If the exposure continues, it leads to genetic mutations and affects protein synthesis. Small cell lung cancer (SCLC) represents 13% of all lung cancer cases diagnosed in the United States. Although a chemotherapy- and radiation-sensitive disease, SCLC recurs rapidly with only 5% of patients surviving five years. This dismal prognosis likely is secondary to few improvements in its treatment. Radiation therapy is only an option for patients who are not surgical candidates. Medical Oncology. Because the majority of lung adenocarcinomas are incurable or advanced, chemotherapy is often used. Despite significant advances in chemotherapy, the survival of most patients with lung adenocarcinoma remains by: 1. Lung Cancer Treatment and Research Content This book describes the molecular mechanisms of lung cancer development and progression that determine therapeutic interventions in the era of genomics, when the rapid evolution in lung cancer diagnosis and treatment necessitates critical review of new results to integrate advances into practice.

  Lung cancer is a major cause of cancer-related deaths in men and women. However, since the first edition of Lung Cancer was published 14 years ago, rapid progress in the biology, prevention, diagnosis, and treatment of the disease has been made. An Overview of Lung Cancer Symptoms, Pathophysiology, And Treatment Patients with lung cancer can provide treatment challenges for even the most skilled clinician. More than 90% of adults with lung cancer are symptomatic when they are diagnosed. According to Van Cleave and Cooley (), a minority of patients present with local symptoms File Size: KB. Small cell lung cancer (SCLC) represents 13% of all lung cancer cases diagnosed in the United States. Although a chemotherapy- and radiation-sensitive disease, SCLC recurs rapidly with only 5% of patients surviving five by: BOOK REVIEW Textbook of Lung Cancer, 2nd edition European Organization for the Research and Treatment and Cancer Phase III randomized trial (Slotman et al.), establishing a role for prophylactic cranial irradiation in extensive stage disease, or a discussion of the possible role for thoracic radiotherapy in extensive stage disease.

mary cause of cancer, and the pathogenesis of cancer is seen as a process of transformation of a normal cell into a tumor cell, as evidenced by deep fundamental research of the pathogenesis of cancer, which is held exclusively at the cellular, molecular and genetic levels of the organism [1] [2]. Such a vector of the scientific researchFile Size: KB.   Lung cancer is the major cancer killer worldwide, and 5-yr survival is extremely poor (≤15%), accentuating the need for more effective therapeutic strategies. Significant advances in lung cancer biology may lead to customised therapy based on targeting specific genes and pathways. The main signalling pathways that could provide roadmaps for therapy include the following: growth Cited by: After treatment for lung cancer, you may experience shortness of breath, and you may find you have less endurance even during simple activities such as walking or shopping. You may also find it difficult to keep your lungs clear of congestion. Pathophysiology is the study of the functional changes that accompany a particular disease. The pathophysiology of lung cancer is complex and still not completely understood; however, the understanding of the pathophysiology of lung cancer has advanced over ists have determined that lung cancer develops from a number of factors.